Live Compliance Alerts
FDA Warning Letters +34% in 2025 — Data Integrity deficiencies lead citations
ISO 42001:2023 AI Management System — Now enforcement-referenced by EU AI Act Art. 13
EU GMP Annex 11 — Computerised system cloud deployments under increased EMA scrutiny
GAMP 5 2nd Edition — FDA CSA alignment mandates critical thinking over documentation volume
21 CFR Part 11 — Missing audit trail reviews remain top-5 483 citation category
NIST AI RMF 1.0 — Referenced in FDA guidance on AI/ML Software as Medical Device (SaMD)
ICH Q10 — Senior management oversight documentation gaps flagged in 2025 inspections
ISO 13485:2016 — EU MDR transitional period ends; full compliance required across supply chain
FDA Warning Letters +34% in 2025 — Data Integrity deficiencies lead citations
ISO 42001:2023 AI Management System — Now enforcement-referenced by EU AI Act Art. 13
EU GMP Annex 11 — Computerised system cloud deployments under increased EMA scrutiny
GAMP 5 2nd Edition — FDA CSA alignment mandates critical thinking over documentation volume
21 CFR Part 11 — Missing audit trail reviews remain top-5 483 citation category
NIST AI RMF 1.0 — Referenced in FDA guidance on AI/ML Software as Medical Device (SaMD)
ICH Q10 — Senior management oversight documentation gaps flagged in 2025 inspections
ISO 13485:2016 — EU MDR transitional period ends; full compliance required across supply chain
Life Sciences · Pharmaceutical · Biotech · Medical Device

An FDA inspection shouldn't be your first audit.

Expert computer system validation and regulatory compliance consulting for pharmaceutical, biotech, and medical device companies — globally, affordably, and without compromise.

From Continuous Compliance to Total Audit Readiness.

21+
Regulatory frameworks
covered
90
Days to audit
readiness
24hr
Proposal
turnaround
100%
Risk-based
methodology
RACQV COMPLIANCE DASHBOARD
21 CFR PART 11COVERED
EU GMP ANNEX 11COVERED
GAMP 5 2ND ED.COVERED
ISO 42001:2023COVERED
NIST AI RMF 1.0COVERED
ISO 13485:2016COVERED
AUDIT READINESSASSESS NOW
DOCUMENTATION GAPREVIEW NEEDED
The Stakes

The price of an FDA Warning Letter.

Non-compliance isn't just a regulatory problem — it's a business-ending event.

Import Alerts
FDA can block all products from your facility from entering the US market — immediately, without warning.
Avg Revenue Loss
$2M – $50M+
⚖️
Consent Decrees
Forced shutdown of manufacturing operations, third-party oversight, and years of remediation at your expense.
Remediation Cost
$100M+
📉
Reputational Damage
Warning Letters are public. Customers, partners, and investors see every citation — and they act accordingly.
Market Impact
Irreversible
Core Services

What we deliver.

End-to-end compliance consulting — from initial gap analysis through audit readiness and ongoing monitoring.

01
🖥️
Computer System Validation
Full CSV lifecycle from URS through VSR. GAMP 5 methodology, FDA 21 CFR Part 11 compliant, risk-based approach for all GxP systems including LIMS, MES, ERP, and clinical systems.
21 CFR Part 11GAMP 5IQ/OQ/PQ
02
⚗️
Equipment Qualification
DQ, IQ, OQ, and PQ for manufacturing and laboratory equipment aligned with FDA, EMA, and ICH Q guidelines. From analytical instruments to automated production systems.
DQ/IQ/OQ/PQICH Q10GMP
03
🔍
Regulatory Gap Analysis
Comprehensive assessment against applicable regulations. Identify deficiencies, prioritize remediation, build a structured compliance roadmap before the auditors do it for you.
Gap AssessmentCAPARoadmap
04
📁
Documentation & SOPs
Author, review, and remediate SOPs, Validation Protocols, and Master Plans with full audit trail compliance. Every document inspection-ready from day one.
SOPsValidation PlansAudit Trail
05
🛡️
Mock FDA Audits
Simulate FDA inspections using current protocols. Identify vulnerabilities before regulators do — with full 483 response preparation included.
FDA 483Inspection PrepResponse Plans
06
🤖
AI Governance & Compliance
Structured AI governance for regulated industries. ISO 42001 implementation, NIST AI RMF alignment, human-in-the-loop design, and AI/ML validation for GxP systems.
ISO 42001NIST AI RMFSaMD
Industries Served

Built for regulated industries.

Every industry faces a different regulatory landscape. We know yours.

💊
Pharmaceutical
FDA · EMA · ICH
GMP · GDP · GLP
21 CFR 210/211
🧬
Biotech
FDA BLA/IND
GCP · GAMP 5
Data Integrity
🏥
Medical Device
FDA 510k/PMA
ISO 13485 · MDR
21 CFR Part 820
🔬
Clinical Research
GCP · ICH E6
21 CFR Part 11
CTMS Validation
Our Approach

Compliance as a strategic asset.

Our 7-step framework transforms regulatory requirements into operational strength.

01
Regulatory Mapping
Identify all applicable frameworks for your industry and geography
02
Gap Analysis
Evaluate current state vs. required standards and quantify deficiencies
03
Policy Development
Draft procedures and establish training and accountability structures
04
Technology
Deploy compliant LMS, document control, and RegTech tools
05
Culture
Embed compliance across your organization through training
06
Monitoring
Ongoing audits, risk reassessments, regulatory update tracking
07
Audit Readiness
Full documentation, secure storage, instant retrieval for any regulator
Engagement Models

Transparent, flexible pricing.

Fixed-fee projects, defined deliverables. No hourly billing surprises.

Assessment
$2,500 starting
For organizations that need to understand their compliance posture before committing to a full remediation program.
  • Regulatory gap analysis (1 system or process)
  • Written findings report with risk ratings
  • Remediation roadmap with prioritized actions
  • 1-hour debrief call with findings walkthrough
  • Delivered within 10 business days
Most clients use this to scope a larger engagement
Most Requested
Project
$8,000 – $35,000
For defined validation or compliance projects with clear scope, deliverables, and timelines. Fixed-fee with milestone billing.
  • Full CSV lifecycle (URS through VSR)
  • All validation protocols (IQ/OQ/PQ)
  • Risk assessment documentation
  • Traceability matrix
  • SOP authoring and review
  • Inspection-ready documentation package
  • 90-day post-delivery support
Retainer
$3,500 / month
Ongoing compliance support, continuous monitoring, and rapid response to regulatory changes or FDA observations.
  • Dedicated compliance advisor
  • Up to 20 hours/month consulting
  • Monthly regulatory update briefings
  • 483 observation response support
  • SOP and document maintenance
  • Priority response within 4 business hours
  • Quarterly compliance health reviews
3-month minimum · 30-day cancellation notice
Need something custom? Large-scale remediation programs, multi-site deployments, and AI governance frameworks are scoped individually. All engagements include a free 30-minute discovery call. Schedule yours →
Regulatory Intelligence

Global compliance library.

Structured regulatory breakdowns across FDA, EU, ISO, AI governance, and privacy frameworks.

FDA
FDA 21 CFR Part 11
Electronic Records & Electronic Signatures
Critical
EU GMP
EU GMP Annex 11
Computerised Systems
High Priority
ISPE
GAMP 5 (2nd Edition)
Risk-Based Computer System Validation
Industry Standard
ICH
ICH Q10
Pharmaceutical Quality System
Global
ISO
ISO 13485:2016
Medical Device Quality Management
Medical Device
AI Governance
ISO 42001:2023
AI Management System
Emerging Standard
NIST
NIST AI RMF 1.0
AI Risk Management Framework
AI Risk
US Healthcare
HIPAA
Health Information Privacy & Security
Privacy
Corporate Governance
Sarbanes-Oxley (SOX)
Financial Reporting Controls
Financial
Validation Artifacts

Validation document templates.

Structured CSV and CSA templates aligned with FDA, GAMP 5, Annex 11, and risk-based validation practices. Free with registration.

VP
Validation Plan
Master plan defining scope, approach, responsibilities, and acceptance criteria for a complete CSV project.
↓ Download Template
URS
User Requirements Specification
Structured template for capturing functional and compliance requirements before system design.
↓ Download Template
IQ
Installation Qualification
Verification that the system is installed correctly per approved specifications.
↓ Download Template
OQ
Operational Qualification
Demonstration that the system operates consistently within defined parameters.
↓ Download Template
PQ
Performance Qualification
Evidence demonstrating consistent performance under routine production conditions.
↓ Download Template
RA
Risk Assessment
GAMP 5 and ICH Q9 aligned risk assessment template for GxP computer systems.
↓ Download Template
Compliance Insights

Intelligence for regulated teams.

Practical analysis of regulatory developments, enforcement trends, and validation best practices.

FDAWarning Letters
June 2026
FDA Warning Letters Up 34% in 2025: What Regulated Manufacturers Need to Know
Data integrity deficiencies, inadequate validation documentation, and audit trail failures continue to dominate 483 observations — with escalation to Warning Letters at record rates.
Read Analysis →
AI GovernanceISO 42001
May 2026
ISO 42001:2023 in Life Sciences: What Pharmaceutical AI Teams Must Document Now
As AI systems penetrate clinical decision support, pharmacovigilance, and drug discovery, the world's first AI management standard is becoming a compliance baseline — not an aspiration.
Read Analysis →
GAMP 5CSV
April 2026
GAMP 5 Second Edition: The Shift from Documentation Volume to Critical Thinking
The 2022 Second Edition fundamentally reframes how validation evidence is generated. Risk-based testing and meaningful assurance replace checkbox compliance — and FDA's CSA guidance aligns with it.
Read Analysis →
Get Started

Don't wait for a 483 to find out.

Tell us about your project. We'll respond within 24 hours with a tailored proposal — no obligation, no boilerplate. Most clients are audit-ready within 90 days.

24-hour proposal turnaround
Every inquiry receives a tailored response, not a template — within one business day.
Free 30-minute discovery call
We scope every engagement with a structured discovery call at no charge.
Fixed-fee project pricing
No hourly billing surprises. Project engagements are scoped and priced upfront.
Confidentiality guaranteed
All project details held in strict confidence. NDAs available on request.
Direct Contact
hello@alyphcsv.com
Alyph RACQV
Project Brief
✓ Received. We'll respond within 24 hours with a tailored proposal. Check your email at
📥 Download Template

Enter your information to access this free validation document template.

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